PLP2 of mouse hepatitis virus A59 (MHV-A59) targets TBK1 to negatively regulate cellular type I interferon signaling pathway.
Identifieur interne : 002069 ( Main/Exploration ); précédent : 002068; suivant : 002070PLP2 of mouse hepatitis virus A59 (MHV-A59) targets TBK1 to negatively regulate cellular type I interferon signaling pathway.
Auteurs : Gang Wang [République populaire de Chine] ; Gang Chen ; Dahai Zheng ; Genhong Cheng ; Hong TangSource :
- PloS one [ 1932-6203 ] ; 2011.
Descripteurs français
- KwdFr :
- Animaux, Cellules cultivées, Interféron de type I (métabolisme), Interféron de type I (physiologie), Maturation post-traductionnelle des protéines (génétique), Maturation post-traductionnelle des protéines (physiologie), Papaïne (), Papaïne (génétique), Papaïne (métabolisme), Protein-Serine-Threonine Kinases (antagonistes et inhibiteurs), Protein-Serine-Threonine Kinases (métabolisme), Protéines virales non structurales (), Protéines virales non structurales (génétique), Protéines virales non structurales (métabolisme), Protéines virales non structurales (physiologie), Souris, Structure tertiaire des protéines (génétique), Structure tertiaire des protéines (physiologie), Transduction du signal (génétique), Transduction du signal (physiologie), Transfection, Ubiquitinylation (génétique), Virus de l'hépatite murine (enzymologie), Virus de l'hépatite murine (métabolisme).
- MESH :
- antagonistes et inhibiteurs : Protein-Serine-Threonine Kinases.
- enzymologie : Virus de l'hépatite murine.
- génétique : Maturation post-traductionnelle des protéines, Papaïne, Protéines virales non structurales, Structure tertiaire des protéines, Transduction du signal, Ubiquitinylation.
- métabolisme : Interféron de type I, Papaïne, Protein-Serine-Threonine Kinases, Protéines virales non structurales, Virus de l'hépatite murine.
- physiologie : Interféron de type I, Maturation post-traductionnelle des protéines, Protéines virales non structurales, Structure tertiaire des protéines, Transduction du signal.
- Animaux, Cellules cultivées, Papaïne, Protéines virales non structurales, Souris, Transfection.
English descriptors
- KwdEn :
- Animals, Cells, Cultured, Interferon Type I (metabolism), Interferon Type I (physiology), Mice, Murine hepatitis virus (enzymology), Murine hepatitis virus (metabolism), Papain (chemistry), Papain (genetics), Papain (metabolism), Protein Processing, Post-Translational (genetics), Protein Processing, Post-Translational (physiology), Protein Structure, Tertiary (genetics), Protein Structure, Tertiary (physiology), Protein-Serine-Threonine Kinases (antagonists & inhibitors), Protein-Serine-Threonine Kinases (metabolism), Signal Transduction (genetics), Signal Transduction (physiology), Transfection, Ubiquitination (genetics), Viral Nonstructural Proteins (chemistry), Viral Nonstructural Proteins (genetics), Viral Nonstructural Proteins (metabolism), Viral Nonstructural Proteins (physiology).
- MESH :
- chemical , antagonists & inhibitors : Protein-Serine-Threonine Kinases.
- chemical , chemistry : Papain, Viral Nonstructural Proteins.
- chemical , genetics : Papain, Viral Nonstructural Proteins.
- chemical , metabolism : Interferon Type I, Papain, Protein-Serine-Threonine Kinases, Viral Nonstructural Proteins.
- chemical , physiology : Interferon Type I, Viral Nonstructural Proteins.
- enzymology : Murine hepatitis virus.
- genetics : Protein Processing, Post-Translational, Protein Structure, Tertiary, Signal Transduction, Ubiquitination.
- metabolism : Murine hepatitis virus.
- physiology : Protein Processing, Post-Translational, Protein Structure, Tertiary, Signal Transduction.
- Animals, Cells, Cultured, Mice, Transfection.
Abstract
Coronaviruses such as severe acute respiratory syndrome (SARS) coronavirus (SCoV) and mouse hepatitis virus A59 (MHV-A59) have evolved strategies to disable the innate immune system for productive replication and spread of infection. We have previously shown that papain-like protease domain 2 (PLP2), a catalytic domain of the nonstructural protein 3 (nsp3) of MHV-A59, encodes a deubiquitinase (DUB) and inactivates IFN regulatory factor 3 (IRF3) thereby the type I interferon (IFN) response.
DOI: 10.1371/journal.pone.0017192
PubMed: 21364999
Affiliations:
Links toward previous steps (curation, corpus...)
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Le document en format XML
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cultivées</term><term>Papaïne</term><term>Protéines virales non structurales</term><term>Souris</term><term>Transfection</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Coronaviruses such as severe acute respiratory syndrome (SARS) coronavirus (SCoV) and mouse hepatitis virus A59 (MHV-A59) have evolved strategies to disable the innate immune system for productive replication and spread of infection. We have previously shown that papain-like protease domain 2 (PLP2), a catalytic domain of the nonstructural protein 3 (nsp3) of MHV-A59, encodes a deubiquitinase (DUB) and inactivates IFN regulatory factor 3 (IRF3) thereby the type I interferon (IFN) response.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><noCountry><name sortKey="Chen, Gang" sort="Chen, Gang" uniqKey="Chen G" first="Gang" last="Chen">Gang Chen</name><name sortKey="Cheng, Genhong" sort="Cheng, Genhong" uniqKey="Cheng G" first="Genhong" last="Cheng">Genhong Cheng</name><name sortKey="Tang, Hong" sort="Tang, Hong" uniqKey="Tang H" first="Hong" last="Tang">Hong Tang</name><name sortKey="Zheng, Dahai" sort="Zheng, Dahai" uniqKey="Zheng D" first="Dahai" last="Zheng">Dahai Zheng</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Wang, Gang" sort="Wang, Gang" uniqKey="Wang G" first="Gang" last="Wang">Gang Wang</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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